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Rethinking the approach to cancer

Nu.Q™ represents a powerful step-change in rethinking the approach to cancer. It is a simple solution to the challenging problem of early cancer diagnosis.

Nu.Q’s unique technology looks for very early ‘nucleosomic’ markers of cancer.

Nu.Q uses an array of simple, cost-effective, and accurate blood tests.

These tests identify early stage cells before the cancer spreads.

Giving medical professionals increased diagnostic power

Early diagnosis informs and reassures patients.

Nu.Q can reduce the strain on over-burdened healthcare systems.

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How it works

Cancer leads to irregular levels of uniquely structured nucleosomes in the blood. Through a simple test, with a small amount of blood, we are able to detect those unique nucleosomes; and by measuring and analyzing them, our Nu.Q tests can identify patients who may have a cancer. This must be confirmed by follow up procedures - for example, for colorectal cancer a colonoscopy must be performed.

How is Nu.Q different to circulating tumor DNA (ctDNA)?

When a cancer cell dies, the nuclear components are metabolized into 20 million individual DNA-Nu complexes and released into circulation. A cancer mutation will occur in one of the DNA-Nu complexes.

Nu.Q targets ALL of the 20 million circulating DNA-Nu complexes because nucleosome modifications occur globally.

ctDNA sequencing methods (in development) must target that one-in-a-million DNA-Nu complex.

We look at a whole haystack, not just the needle.

Volition has developed a suite of novel, routine blood tests for epigenetically altered circulating nucleosomes as biomarkers in cancer. We can incorporate other off-patent, low-cost ELISA tests into our panels (e.g.; CEA) for improved accuracy.

Product Strategy

We plan to develop multiple Nu.Q products across the whole range of cancers falling into the following categories:

  • Frontline General Population Screening Tests

    For asymptomatic subjects for the most prevalent cancers.

  • High Risk Screening ‘Triage’ Tests

    To work in conjunction with existing tests to improve sensitivity and/or specificity.

  • Frontline Diagnostic Tests

    To aid the diagnosis of diseases in symptomatic patients.

  • Disease Monitoring Tests

    To help monitor high risk groups and/or identify the recurrence of a disease.

  • Treatment Selection Tests

    A personalized medicine approach to help identify the most appropirate treatment for the individual.

Current data on the Nu.Q™ platform

We currently have many large ongoing clinical trials, please click on the bubbles to see the current data we have on the Nu.Q platform.


  • Colorectal Cancer

    In a colorectal cancer cohort (123 subjects) a single Nu.Q assay detected colorectal cancer with an AUC of 72%

    In the same cohort a two-assay panel detected all stages of colorectal cancer including stage I and had an AUC of 84% (cancer vs healthy)


  • Lung Cancer

    In a small lung cancer cohort (76 subjects) a single Nu.Q assay detected lung cancer including stage I lung cancer. The AUC for this single Nu.Q assay was 85%

    In a second lung cancer cohort (152 subjects) the AUC for this single Nu.Q assays was 79% and again this performance was further improved when used in a two-assay panel

  • Prostate Cancer

    In a pilot study of 84 men, a panel of 5 assays (including PSA) identified 94% of high-grade prostate cancers that require treatment (as defined by the Gleason Score) at 88% specificity.

    This compares with just 33% identified by PSA alone.

  • Nucleosomes can be detected in dogs and horses. Further proof of concept work underway

  • With Nu.Q Capture we have been able to deplete nucelsomes by 70-90% using magnetic beads in serum and plasma

Research use only kits

Based on our proprietary Nucleosomics the Research Use Only Kits are expected to:

- Allow researchers to explore patterns of epigenetic modifications in circulating nucleosomes across a broad range of clinical applications including cancers, inflammatory and infectious diseases; and

- Represent the first revenue from the Nu.Q platform and potentially provide an additional licensing revenue stream beyond the commercialization of our blood-based cancer tests utilizing the same platform of assays.

The kits are available to purchase through our distributor Active Motif.

Clinical Evidence
Report Small
A novel approach to reducing the impact of colorectal cancer
Investor Press
Detection of colorectal cancer and adenomas by epigenetic profiles of circulating nucleosomes: a pilot study with 58 subjects
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Circulating nucleosomes as new blood-based biomarkers for detection of colorectal cancer
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